MR (TOP300)
ID : Ahg495266
| Gene coexpression | ||
|---|---|---|
| MR | Locus | A.thaliana Description |
| 3.4641 | Ahg480493 | profilin 1 |
| 3.87298 | Ahg922444 | D111/G-patch domain-containing protein |
| 6.32456 | Ahg890682 | P-loop containing nucleoside triphosphate hydrolases superfamily protein |
| 9.53939 | Ahg475208 | LisH and RanBPM domains containing protein |
| 11.4891 | Ahg937302 | Histidyl-tRNA synthetase 1 |
| 12.2474 | Ahg923455 | P-loop containing nucleoside triphosphate hydrolases superfamily protein |
| 12.8062 | Ahg496691 | regulatory particle non-ATPase subunit 5B |
| 13.2665 | Ahg475897 | PAS domain-containing protein tyrosine kinase family protein |
| 16.7929 | Ahg478740 | mitogen-activated protein kinase kinase kinase 7 |
| 19.975 | Ahg487516 | Protein of unknown function (DUF810) |
| 20.7846 | Ahg474047 | stomatal cytokinesis defective / SCD1 protein (SCD1) |
| 21.4476 | Ahg486936 | HEAT repeat-containing protein |
| 22.7596 | Ahg899624 | natural resistance-associated macrophage protein 3 |
| 23.2164 | Ahg945645 | Clathrin adaptor complexes medium subunit family protein |
| 25.923 | Ahg920383 | DYNAMIN-like 1C |
| 30.5941 | Ahg474386 | Peptidase S24/S26A/S26B/S26C family protein |
| 31.4006 | Ahg487909 | Protein of unknown function (DUF1336) |
| 34.3511 | Ahg942945 | SPA1-related 2 |
| 34.4093 | Ahg938716 | Protein of unknown function (DUF288) |
| 34.4674 | Ahg479746 | putative mitochondrial RNA helicase 2 |
| 37.1483 | Ahg489001 | Protein kinase superfamily protein |
| 39 | Ahg918994 | Transcription factor TFIIE, alpha subunit |
| 39.7492 | Ahg475221 | plus-3 domain-containing protein |
| 43.6807 | Ahg478188 | HEAT repeat ;WD domain, G-beta repeat protein protein |
| 44.3621 | Ahg485445 | Phosphatidic acid phosphatase (PAP2) family protein |
| 44.9778 | Ahg471075 | Adenine nucleotide alpha hydrolases-like superfamily protein |
| 46.1302 | Ahg474140 | target of rapamycin |
| 46.9894 | Ahg495060 | DHHC-type zinc finger family protein |
| 48.3735 | Ahg358769 | Major facilitator superfamily protein |
| 48.4665 | Ahg934335 | TSL-kinase interacting protein 1 |
| 54.6717 | Ahg923008 | NRAMP metal ion transporter 2 |
| 58.1378 | Ahg950958 | MEI2-like protein 1 |
| 64.5368 | Ahg484400 | O-fucosyltransferase family protein |
| 68.3667 | Ahg914916 | Polynucleotidyl transferase, ribonuclease H-like superfamily protein |
| 69.6491 | Ahg328837 | no pollen germination related 2 |
| 73.1779 | Ahg488118 | Emsy N Terminus (ENT)/ plant Tudor-like domains-containing protein |
| 74.1418 | Ahg483691 | WD-40 repeat family protein / beige-related |
| 75.8947 | Ahg484006 | Tudor/PWWP/MBT domain-containing protein |
| 79.1454 | Ahg482752 | origin recognition complex second largest subunit 2 |
| 79.7496 | Ahg473269 | cation-chloride co-transporter 1 |
| 82.4742 | Ahg890991 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein |
| 84.4985 | Ahg496574 | Regulator of chromosome condensation (RCC1) family protein |
| 84.7113 | Ahg490265 | oxidoreductase, 2OG-Fe(II) oxygenase family protein |
| 92.5635 | Ahg938355 | Forkhead-associated (FHA) domain-containing protein |
| 95.4673 | Ahg492127 | hydroxyproline-rich glycoprotein family protein |
| 99.2875 | Ahg470455 | potassium channel beta subunit 1 |
| 99.6092 | Ahg478557 | Aha1 domain-containing protein |
| 101.587 | Ahg939309 | RING/U-box superfamily protein |
| 105.717 | Ahg476512 | transducin family protein / WD-40 repeat family protein |
| 106.546 | Ahg487229 | UDP-Glycosyltransferase superfamily protein |
| 108.747 | Ahg484543 | golgin candidate 6 |
| 109.243 | Ahg490219 | pre-mRNA splicing factor-related |
| 109.955 | Ahg931157 | proline iminopeptidase |
| 110.499 | Ahg932706 | Mitochondrial substrate carrier family protein |
| 113.446 | Ahg491051 | early-responsive to dehydration stress protein (ERD4) |
| 113.701 | Ahg484092 | microtubule-associated proteins 70-3 |
| 113.982 | Ahg491627 | DDB1-CUL4 associated factor 1 |
| 115.931 | Ahg493647 | yeast YAK1-related gene 1 |
| 116.726 | Ahg920352 | Mitochondrial substrate carrier family protein |
| 117.162 | Ahg487450 | DNAJ heat shock N-terminal domain-containing protein |
| 117.771 | Ahg939058 | eukaryotic translation initiation factor 4G |
| 119.75 | Ahg493298 | Cysteine proteinases superfamily protein |
| 120.955 | Ahg476363 | NagB/RpiA/CoA transferase-like superfamily protein |
| 121.655 | Ahg929422 | RING/U-box superfamily protein |
| 127.216 | Ahg930502 | BLISTER |
| 127.381 | Ahg949921 | myosin heavy chain-related |
| 128.499 | Ahg492396 | RAB geranylgeranyl transferase alpha subunit 1 |
| 128.942 | Ahg479152 | response regulator 1 |
| 129.093 | Ahg494737 | Zinc finger C-x8-C-x5-C-x3-H type family protein |
| 129.209 | Ahg900162 | Glutamine amidotransferase type 1 family protein |
| 129.831 | Ahg494356 | ornithine-delta-aminotransferase |
| 129.846 | Ahg495103 | exocyst subunit exo70 family protein F1 |
| 130.223 | Ahg945006 | pathogenesis related homeodomain protein A |
| 131.156 | Ahg476241 | Auxin efflux carrier family protein |
| 131.757 | Ahg348567 | dentin sialophosphoprotein-related |
| 132.049 | Ahg928421 | |
| 132.695 | Ahg496904 | Pyridoxal phosphate (PLP)-dependent transferases superfamily protein |
| 133.993 | Ahg477100 | RING/FYVE/PHD zinc finger superfamily protein |
| 134.7 | Ahg478789 | heat shock protein 60-3A |
| 134.967 | Ahg938377 | general control non-repressible 4 |
| 135.093 | Ahg473651 | APR-like 4 |
| 136.821 | Ahg890208 | NPR1-like protein 4 |
| 138.477 | Ahg476412 | translocase inner membrane subunit 23-2 |
| 138.996 | Ahg476875 | Uncharacterised protein family UPF0090 |
| 139.599 | Ahg943823 | HEAT repeat ;HECT-domain (ubiquitin-transferase) |
| 141.849 | Ahg482583 | translocase inner membrane subunit 44-2 |
| 144.962 | Ahg489475 | TCP-1/cpn60 chaperonin family protein |
| 146.335 | Ahg898366 | DNA binding;ATP binding;nucleic acid binding;binding;helicases;ATP binding;DNA binding;helicases |
| 147.77 | Ahg328161 | Adenine nucleotide alpha hydrolases-like superfamily protein |
| 147.878 | Ahg472436 | serine hydroxymethyltransferase 6 |
| 148.31 | Ahg923473 | TBP-associated factor 15 |
| 149.245 | Ahg480562 | high-affinity nickel-transport family protein |
| 152 | Ahg949658 | polyadenylate-binding protein 1 |
| 152.21 | Ahg474549 | CTC-interacting domain 3 |
| 156.234 | Ahg472969 | U2 snRNP auxiliary factor small subunit, putative |
| 158 | Ahg913850 | Protein kinase superfamily protein |
| 160.062 | Ahg480601 | ubiquitin family protein |
| 160.984 | Ahg480298 | Major facilitator superfamily protein |
| 160.997 | Ahg921434 | F-box family protein |
| 162.991 | Ahg924045 | calpain-type cysteine protease family |
| 165.988 | Ahg471898 | KU70 homolog |
| 166.853 | Ahg495758 | Class II aminoacyl-tRNA and biotin synthetases superfamily protein |
| 168.861 | Ahg487366 | sequence-specific DNA binding transcription factors;zinc ion binding;sequence-specific DNA binding transcription factors |
| 169.183 | Ahg324657 | Protein kinase superfamily protein |
| 169.617 | Ahg926773 | Transmembrane Fragile-X-F-associated protein |
| 173.781 | Ahg327675 | pentatricopeptide (PPR) repeat-containing protein |
| 174.413 | Ahg477969 | PAS domain-containing protein tyrosine kinase family protein |
| 175.317 | Ahg943901 | phenylalanyl-tRNA synthetase, putative / phenylalanine--tRNA ligase, putative |
| 176.068 | Ahg484506 | Cytochrome C1 family |
| 177.71 | Ahg475241 | U2 snRNP auxilliary factor, large subunit, splicing factor |
| 178.267 | Ahg479501 | Calcium-dependent lipid-binding (CaLB domain) family protein |
| 178.342 | Ahg480100 | anaphase-promoting complex/cyclosome 2 |
| 178.415 | Ahg478459 | alfin-like 2 |
| 181.083 | Ahg495041 | Protein of unknown function, DUF647 |
| 181.59 | Ahg951497 | SKP1/ASK1-interacting protein 2 |
| 182.085 | Ahg944366 | isocitrate dehydrogenase 1 |
| 182.636 | Ahg485534 | transmembrane protein G1P-related 1 |
| 184.304 | Ahg921297 | MA3 domain-containing protein |
| 185.184 | Ahg477362 | DEAD box RNA helicase 1 |
| 185.394 | Ahg472149 | DA1 |
| 188.234 | Ahg494293 | RNA-binding (RRM/RBD/RNP motifs) family protein |
| 188.611 | Ahg475845 | glucosidase 1 |
| 188.892 | Ahg479967 | proline extensin-like receptor kinase 1 |
| 189.352 | Ahg486525 | ATP-dependent caseinolytic (Clp) protease/crotonase family protein |
| 190.352 | Ahg496189 | DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain |
| 190.853 | Ahg325922 | pescadillo-related |
| 191.677 | Ahg486239 | sumo conjugation enzyme 1 |
| 194.152 | Ahg477298 | hydroxyproline-rich glycoprotein family protein |
| 196.097 | Ahg923497 | indigoidine synthase A family protein |
| 198.567 | Ahg914578 | Eukaryotic translation initiation factor 2B (eIF-2B) family protein |
| 198.972 | Ahg492266 | C2H2-like zinc finger protein |
| 199.902 | Ahg475225 | cleavage and polyadenylation specificity factor 73-I |
| 200.24 | Ahg473331 | Integral membrane HRF1 family protein |
| 201.618 | Ahg496832 | P-loop containing nucleoside triphosphate hydrolases superfamily protein |
| 202.228 | Ahg487690 | Pentatricopeptide repeat (PPR) superfamily protein |
| 202.583 | Ahg488140 | transcription regulators |
| 202.643 | Ahg476019 | WPP domain-interacting protein 2 |
| 205.949 | Ahg930446 | RNA recognition motif (RRM)-containing protein |
| 210.599 | Ahg483634 | Translation elongation factor EFG/EF2 protein |
| 213.282 | Ahg479521 | protein arginine methyltransferase 6 |
| 215.499 | Ahg471803 | Protein of unknown function (DUF1712) |
| 216.573 | Ahg926713 | Endosomal targeting BRO1-like domain-containing protein |
| 217.048 | Ahg488835 | calcium-dependent protein kinase 19 |
| 217.453 | Ahg487745 | NAC domain containing protein 82 |
| 219.773 | Ahg944707 | ATPase, F0/V0 complex, subunit C protein |
| 219.964 | Ahg478525 | |
| 221.011 | Ahg488386 | U-box domain-containing protein |
| 221.088 | Ahg486261 | |
| 222.991 | Ahg482413 | mitochondrial ribosomal protein S14 |
| 223.428 | Ahg473468 | ubiquitin-specific protease 11 |
| 224.66 | Ahg480549 | multimeric translocon complex in the outer envelope membrane 132 |
| 224.944 | Ahg323092 | aldehyde oxidase 2 |
| 225.071 | Ahg492340 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein |
| 230.272 | Ahg937906 | Cytochrome P450 superfamily protein |
| 230.486 | Ahg329195 | modifier of snc1 |
| 231.376 | Ahg488554 | cellulose-synthase like D2 |
| 240.988 | Ahg492708 | C-terminal domain phosphatase-like 1 |
| 243.047 | Ahg927706 | Flavodoxin family protein |
| 244.483 | Ahg484196 | Galactose oxidase/kelch repeat superfamily protein |
| 244.869 | Ahg482666 | glucan synthase-like 8 |
| 246.414 | Ahg927059 | Tetratricopeptide repeat (TPR)-like superfamily protein |
| 246.635 | Ahg484792 | RING/FYVE/PHD-type zinc finger family protein |
| 247.919 | Ahg494223 | RGPR-related |
| 248.948 | Ahg488831 | Regulator of chromosome condensation (RCC1) family with FYVE zinc finger domain |
| 249.415 | Ahg930539 | Alcohol dehydrogenase transcription factor Myb/SANT-like family protein |
| 249.972 | Ahg475877 | beta-ketoacyl reductase 1 |
| 250.4 | Ahg927930 | Protein kinase family protein |
| 251.321 | Ahg337633 | RING/U-box superfamily protein |
| 252.236 | Ahg496447 | proline-rich family protein |
| 252.701 | Ahg927732 | Pentatricopeptide repeat (PPR) superfamily protein |
| 253.673 | Ahg487631 | dentin sialophosphoprotein-related |
| 253.904 | Ahg475439 | Golgi-body localisation protein domain ;RNA pol II promoter Fmp27 protein domain |
| 254.283 | Ahg470470 | ubiquitin-specific protease 2 |
| 254.558 | Ahg940610 | DNAse I-like superfamily protein |
| 257.208 | Ahg472772 | Tetratricopeptide repeat (TPR)-like superfamily protein |
| 257.715 | Ahg488782 | ARM repeat superfamily protein |
| 257.74 | Ahg474357 | Coatomer, beta' subunit |
| 259.027 | Ahg931973 | Secretory carrier membrane protein (SCAMP) family protein |
| 259.729 | Ahg488196 | zinc induced facilitator-like 1 |
| 260.1 | Ahg496786 | Tetratricopeptide repeat (TPR)-like superfamily protein |
| 260.768 | Ahg492725 | vacuolar protein sorting-associated protein 28 homolog 1 |
| 260.91 | Ahg496370 | signal recognition particle-related / SRP-related |
| 262.059 | Ahg484492 | translocase of outer membrane 20 kDa subunit 3 |
| 267.421 | Ahg932732 | embryo defective 2410 |
| 267.769 | Ahg482865 | transcript elongation factor IIS |
| 267.78 | Ahg490214 | glucan synthase-like 5 |
| 268.58 | Ahg920412 | Uncharacterised conserved protein UCP031088, alpha/beta hydrolase |
| 269.913 | Ahg472902 | |
| 270.747 | Ahg495615 | DNA topoisomerase I alpha |
| 271.529 | Ahg347608 | SIT4 phosphatase-associated family protein |
| 275.608 | Ahg476205 | Protein kinase superfamily protein |
| 277.294 | Ahg943011 | bromo-adjacent homology (BAH) domain-containing protein |
| 278.061 | Ahg486210 | adenylosuccinate synthase |
| 278.482 | Ahg477668 | apyrase 1 |
| 279.65 | Ahg920943 | Regulator of chromosome condensation (RCC1) family protein |
| 281.695 | Ahg477830 | acyl-CoA binding protein 4 |
| 282.018 | Ahg927990 | Ankyrin repeat family protein |
| 282.276 | Ahg496246 | Transducin/WD40 repeat-like superfamily protein |
| 285.699 | Ahg495535 | Protein of unknown function (DUF295) |
| 288.215 | Ahg495654 | RNA-binding (RRM/RBD/RNP motifs) family protein |
| 289.703 | Ahg475506 | |
| 290.407 | Ahg927067 | eukaryotic translation initiation factor 2 (eIF-2) family protein |
| 292.139 | Ahg481207 | |
| 292.903 | Ahg924243 | HSP20-like chaperones superfamily protein |
| 293.489 | Ahg482339 | Tyrosyl-tRNA synthetase, class Ib, bacterial/mitochondrial |
| 293.571 | Ahg492344 | SUMO-activating enzyme 1A |
| 294.102 | Ahg492281 | non-intrinsic ABC protein 8 |
| 295.973 | Ahg317994 | KH domain-containing protein / zinc finger (CCCH type) family protein |
| 296.176 | Ahg477431 | galacturonosyltransferase 13 |
| 296.481 | Ahg479648 | dentin sialophosphoprotein-related |
| 297.278 | Ahg496680 | CYS, MET, PRO, and GLY protein 2 |
| 297.574 | Ahg889149 | |
| 299.269 | Ahg928962 | actin-related protein 5 |
| 301.281 | Ahg940670 | Protein kinase superfamily protein |
| 302.175 | Ahg944826 | |
| 305.408 | Ahg495454 | Nucleotidyltransferase family protein |
| 305.473 | Ahg481009 | RNA-binding (RRM/RBD/RNP motifs) family protein |
| 305.882 | Ahg481074 | RING/FYVE/PHD zinc finger superfamily protein |
| 305.966 | Ahg475057 | Chaperone DnaJ-domain superfamily protein |
| 307.701 | Ahg353623 | Octicosapeptide/Phox/Bem1p (PB1) domain-containing protein / tetratricopeptide repeat (TPR)-containing protein |
| 308.626 | Ahg488945 | Octicosapeptide/Phox/Bem1p (PB1) domain-containing protein / tetratricopeptide repeat (TPR)-containing protein |
| 309.587 | Ahg948606 | chromatin remodeling 4 |
| 311.233 | Ahg483494 | Transducin/WD40 repeat-like superfamily protein |
| 311.467 | Ahg941044 | Bromodomain transcription factor |
| 312.84 | Ahg332873 | P-loop containing nucleoside triphosphate hydrolases superfamily protein |
| 313.128 | Ahg486216 | nuclear RNA polymerase A1 |
| 313.621 | Ahg485401 | CDPK-related kinase |
| 314.79 | Ahg933239 | Ring/U-Box superfamily protein |
| 315.751 | Ahg900570 | eukaryotic translation initiation factor 2 family protein / eIF-2 family protein |
| 315.751 | Ahg476765 | Prolyl oligopeptidase family protein |
| 315.929 | Ahg474517 | 20S proteasome alpha subunit E1 |
| 316.938 | Ahg931790 | coatomer gamma-2 subunit, putative / gamma-2 coat protein, putative / gamma-2 COP, putative |
| 317.49 | Ahg930742 | TRAF-like family protein |
| 317.49 | Ahg930741 | TRAF-like family protein |
| 317.49 | Ahg930743 | TRAF-like family protein |
| 317.632 | Ahg484859 | Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family |
| 317.829 | Ahg474726 | NIMA-related serine/threonine kinase 1 |
| 319.844 | Ahg487662 | Succinyl-CoA ligase, alpha subunit |
| 320.13 | Ahg471159 | SIN3-like 6 |
| 321.966 | Ahg489362 | Sas10/Utp3/C1D family |
| 323.94 | Ahg480309 | ARM repeat superfamily protein |
| 324.435 | Ahg487936 | TRS120 |
| 324.438 | Ahg478776 | transmembrane nine 7 |
| 324.651 | Ahg933191 | |
| 325.877 | Ahg480948 | Arabidopsis phospholipase-like protein (PEARLI 4) family |
| 325.911 | Ahg477983 | binding |
| 326.595 | Ahg486562 | dihydrodipicolinate synthase 1 |
| 327.483 | Ahg478119 | RNA-binding (RRM/RBD/RNP motifs) family protein |
| 329.333 | Ahg920270 | calmodulin binding;purine nucleotide binding |
| 330.557 | Ahg482091 | ARM repeat superfamily protein |
| 331.385 | Ahg482541 | DNAJ heat shock N-terminal domain-containing protein |
| 332.904 | Ahg944345 | NADPH-dependent thioredoxin reductase B |
| 333.455 | Ahg336036 | |
| 333.679 | Ahg485035 | zinc finger (C3HC4-type RING finger) family protein |
| 334.04 | Ahg888084 | 14-3-3 family protein |
| 335.766 | Ahg490031 | alpha/beta-Hydrolases superfamily protein |
| 336.679 | Ahg903199 | HSP20-like chaperones superfamily protein |
| 337.519 | Ahg331395 | zinc knuckle (CCHC-type) family protein |
| 338.674 | Ahg487351 | E3 ubiquitin ligase, putative |
| 344.791 | Ahg485669 | CBS / octicosapeptide/Phox/Bemp1 (PB1) domains-containing protein |
| 345.482 | Ahg931619 | Polynucleotide adenylyltransferase family protein |
| 345.827 | Ahg480841 | Transducin/WD40 repeat-like superfamily protein |
| 346.092 | Ahg931380 | Protein of unknown function (DUF810) |
| 346.302 | Ahg471924 | IAP-like protein 1 |
| 346.831 | Ahg492028 | |
| 347.609 | Ahg923648 | ZIM-LIKE 2 |
| 347.986 | Ahg477114 | Aldolase-type TIM barrel family protein |
| 350.599 | Ahg488820 | RNA-binding (RRM/RBD/RNP motifs) family protein |
| 351.001 | Ahg355577 | Polynucleotidyl transferase, ribonuclease H fold protein with HRDC domain |
| 351.078 | Ahg474170 | Ergosterol biosynthesis ERG4/ERG24 family |
| 352.62 | Ahg934754 | ubiquitin-protein ligases |
| 352.829 | Ahg925982 | HCP-like superfamily protein with MYND-type zinc finger |
| 354.33 | Ahg910852 | WAPL (Wings apart-like protein regulation of heterochromatin) protein |
| 358.645 | Ahg892406 | DEA(D/H)-box RNA helicase family protein |
| 360.267 | Ahg489208 | long-chain base (LCB) kinase 1 |
| 360.421 | Ahg943837 | Protein of unknown function (DUF3414) |
| 362.375 | Ahg470311 | Small nuclear ribonucleoprotein family protein |
| 363.091 | Ahg486811 | Tudor/PWWP/MBT domain-containing protein |
| 363.946 | Ahg489600 | Tetratricopeptide repeat (TPR)-like superfamily protein |
| 364.768 | Ahg479495 | |
| 365.764 | Ahg943535 | MUTS homolog 6 |
| 366.377 | Ahg484287 | Translin family protein |
| 368.121 | Ahg494121 | Protein kinase superfamily protein |
| 368.247 | Ahg496130 | RNA-binding (RRM/RBD/RNP motifs) family protein |
| 368.459 | Ahg486427 | diphthamide synthesis DPH2 family protein |
| 370.276 | Ahg497488 | eukaryotic translation initiation factor 2 |
| 373.642 | Ahg494637 | Sec23/Sec24 protein transport family protein |
| 373.738 | Ahg481754 | S-adenosyl-L-methionine-dependent methyltransferases superfamily protein |
| 376.956 | Ahg470642 | Ribosomal protein S5/Elongation factor G/III/V family protein |
| 377.15 | Ahg480812 | nucleic acid binding;zinc ion binding;DNA binding |
| 378.675 | Ahg496377 | diphthamide synthesis DPH2 family protein |
| 378.735 | Ahg484793 | ARID/BRIGHT DNA-binding domain-containing protein |
| 379.359 | Ahg479256 | Protein kinase superfamily protein |
| 379.55 | Ahg924591 | GMP synthase (glutamine-hydrolyzing), putative / glutamine amidotransferase, putative |
| 379.602 | Ahg496276 | conserved peptide upstream open reading frame 15 |
| 380.892 | Ahg951288 | conserved peptide upstream open reading frame 22 |
| 383.487 | Ahg491854 | regulatory particle AAA-ATPase 2A |
| 384.281 | Ahg339978 | alpha/beta-Hydrolases superfamily protein |
| 385.474 | Ahg934611 | Transducin/WD40 repeat-like superfamily protein |
| 386.271 | Ahg911792 | NAD(P)-binding Rossmann-fold superfamily protein |